Christian Eriksen starts with Romelu Lukaku and Lautaro Martinez, as Inter can go top with a victory, but Lazio have won six in a row with Ciro Immobile and Sergej Milinkovic-Savic.
It kicks off at 19.45 GMT at the Stadio Giuseppe Meazza.
You can follow all the build-up and action as it happens and give your views on the LIVEBLOG.
Because Milan lost to Spezia and Juventus fell at Napoli on Saturday, Inter have the opportunity to leap into first place with a win here this evening.
However, Lazio are also hoping to close on the top spot and come into this game with six consecutive Serie A victories under their belts.
Arturo Vidal is out of action and Antonio Conte warned he is also at risk for next week’s Derby della Madonnina showdown.
Rather than Roberto Gagliardini, it’s Christian Eriksen who is given the nod in midfield, an ideal way for the Dane to celebrate his birthday.
Lukaku is looking for his first goal against Lazio, with Lautaro Martinez completing the usual partnership, but Ivan Perisic preferred to Ashley Young.
Samir Handanovic is making his 500th Serie A appearance, which includes one for Lazio in 2006.
Inter need to be wary ahead of the derby, because Marcelo Brozovic, Nicolò Barella and Alessandro Bastoni are all one yellow card away from suspension.
Because it’s Chinese New Year, Inter are wearing special edition jerseys with the player names in Chinese characters.
Simone Inzaghi’s Lazio have found their form lately with six Serie A wins on the bounce.
Luiz Felipe and Thomas Strakosha are still out of action, but Stefan Radu is able to start despite a problem in training on Saturday.
Patric returns from suspension and takes back his spot in defence from Mateo Musacchio.
Joaquin Correa gets the nod with Ciro Immobile, supported by Luis Alberto and Sergej Milinkovic-Savic.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Brozovic, Eriksen, Perisic; Lautaro Martinez, R Lukaku
Inter bench: Padelli, Radu, Gagliardini, Alexis Sanchez, Vecino, Kolarov, Sensi, Ranocchia, Young, D’Ambrosio, Darmian, Pinamonti
Lazio: Reina; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Marusic; Correa, Immobile
Lazio bench: Alia, Pereira, Hoedt, Parolo, Escalante, Lulic, Caicedo, Cataldi, Musacchio, Akpa Akpro, Muriqi, Fares