Roma have Chris Smalling back in the squad to face Fiorentina, but Roger Ibanez and Edin Dzeko are still out of action.
It kicks off on Wednesday at 19.45 GMT, click here for a match preview.
Paulo Fonseca still has some problems to deal with, as Ibanez, Davide Santon, Dzeko, Riccardo Calafiori and Nicolò Zaniolo are on the treatment table.
However, Marash Kumbulla was available on the bench against Milan at the weekend and could start, while Smalling returns to the squad too.
Roma squad for Fiorentina: Pau Lopez, Mirante, Fuzato; Karsdorp, Juan Jesus, Smalling, Fazio, Mancini, Kumbulla, Peres, Spinazzola; Cristante, Pellegrini, Villar, Veretout, Pastore, Diawara, Mkhitaryan; Pedro, Mayoral, Perez, El Shaarawy